6,500+ specialty providersVisit-ready
Keep authorization and coverage aligned before the appointment is booked.
Infectious Disease PM & RCM Software
The Leading Practice Management and RCM Billing Software for Infectious Disease
Streamline antiviral drug authorizations, IV antimicrobial waste billing, and viral load-driven renewal cycles. See why infectious disease practices choose Unlimited Systems for practice management and RCM software.
Why Infectious Disease billing is different
Infectious disease practices navigate extraordinarily complex billing environments, managing HIV prophylaxis programs, antiretroviral drug monitoring, hepatitis C cures, and high-cost IV antimicrobial therapy regimens, all under intense payer scrutiny and strict prior authorization criteria.
A single course of IV antibiotics in an outpatient infusion suite requires simultaneous authorization confirmation, drug waste tracking, nursing administration time billing, and post-treatment laboratory monitoring code sequencing. Generic RCM platforms miss these multi-dimensional claim layers entirely.
★★★★★4.8/5
★★★★★5/5
★★★★★5/5
★★★★★5/5★★★★★5/56,500+ specialty providersSOC 2 certified
Trusted Payer & EHR Integration Partners
.png)
.png)
.png)
.png)
.png)
.png)
.png)
.png)
.png)
.png)
6,500+
providers nationwide
$70B+
in claims processed annually
4.8/5
average client rating
Designed Around How Your Infectious Disease Practice ACTUALLY Works
Our connected workflows are built to make you and your work easier to do and increase your revenue.
Claim-ready
Validate infectious disease codes, modifiers, and documentation before submission.
Practice-ready
Give teams one view of denials, margin, and A/R priorities.
Specialty RCM intelligence
Infectious Disease Revenue Cycle Challenges
Long-acting antiretrovirals and specialty biologics are transforming ID billing.
16%
Est. denial rate
8/10
Prior-auth burden
Where revenue is at risk
HIV Long-Acting Injectable ARVs
Cabenuva monthly or bimonthly injections split between Part B and Part D depending on administration site.
How the platform addresses this
- Injection intervals are validated against documented administration.
- Buy-and-bill margin is modeled per agent and payer.
- Authorization tracks with the injection schedule.
Buy-and-bill drug reference5 agents · codes, channel, prior-auth, and billing notes
| Drug | Code | Route | Channel | Cost | PA | Billing notes |
|---|---|---|---|---|---|---|
| Cabenuva (cab + rilpivirine) | J0740 / J2350 | IM | Part B | $22K/yr | Yes | Monthly or bimonthly; refrigerated; scheduling critical. |
| Sunlenca (lenacapavir) | J0222 | SQ/oral | Part B/D | $42K/yr | Yes | Twice-yearly SQ; payer policy evolving. |
| Vancomycin (IV) | J3370 | IV | Part B | Varies | Sometimes | OPAT; weight-based dosing and trough levels required. |
| Cefepime (IV) | J0692 | IV | Part B | Varies | No | OPAT antibiotic; infusion duration documentation critical. |
| Beyfortus (nirsevimab) | Q2056 | IM | Part B/VFC | $500/dose | Sometimes | RSV prophylaxis; payer coverage rapidly evolving. |
Cabinet integration: ID practices running OPAT services depend heavily on cabinet integration. Weight-based antibiotic dosing makes partial vial wastage routine, and without ADC-to-EHR linkage, JW modifier compliance is hard to maintain at scale.
Hear It From Our Clients
Specialty practices describe, in their own words, what changed after moving to Unlimited Systems.
Video testimonial
Dunmore, Pennsylvania
“As I look back at the transition, the support and the collaboration with the folks at Unlimited really helped make us feel at ease. We had a partner that really wanted us to be successful.”
- CEO
- Days in A/R shrank from 21 to 15, consistently.
- Charges go out the next day.
- Less manual work, more clean claims, and stronger cash flow.
Calculate Your RCM Revenue Leakage
Drag the sliders to estimate how much unrealized cash remains locked in your current specialty billing cycles before optimization.
Model your current claim volume
Adjust both inputs to match your practice.
1,500
200 claims15,000 claims
$250
$80 value$3,500 value
See your recovery estimate
Enter your work email to unlock your estimated annual recovery.
See Your Results ImmediatelyGoogle5/5Gartner5/5G24.8/5
One platform for every infectious disease workflow
Eight connected capabilities, grouped around the way your practice works.
Front office
Keep registration and appointment calendars in sync.
Before the visit
Verify coverage and catch charge risk early.
Revenue cycle
Post payments, route denials, and prioritize A/R.
Practice intelligence
See margin, performance, and value-based results.
The Infectious Disease suite
Every part of the infectious disease revenue cycle, in one system
Each module is configured for the codes, modifiers, and payer rules infectious disease teams work with, not adapted from generic billing software.
Infectious Disease Patient Intake SoftwareVerify HIV, hepatitis, and specialty infectious coverage prior to treatment plan activation.Infectious Disease Scheduling SoftwareCoordinate IV antimicrobial chair times, lab follow-ups, and viral monitoring visits.Infectious Disease Financial Clearance SoftwareAutomate step-therapy requirements and prior auths for HIV antiretrovirals and HCV cures.Infectious Disease Charge Validation SoftwareCalculate IV antimicrobial drug waste units and apply JW/JZ modifiers automatically.Infectious Disease Payment Posting SoftwareReconcile specialty pharmacy invoices against payer remittances for complex drug claims.Infectious Disease AR Management SoftwareFlag high-risk authorization gaps before treatment sessions generate uncollectable losses.Infectious Disease Analytics SoftwareCompare drug acquisition costs, payer spreads, and collection rates per treatment protocol.Infectious Disease Value-Based Care SoftwareSubmit HRSA and MIPS quality measures on viral suppression and HIV screening rates.
The cost of generic billing
You went into infectious disease to treat patients, not to chase claims
These are the places infectious disease practices most often lose revenue when their billing platform wasn’t built for the work. Unlimited Systems closes each one with rules configured for your specialty.
Review your workflowCommon infectious disease revenue leaks
- Recurring prior authorization denials on high-cost antiretroviral and hepatitis C drug regimens.
- Undocumented IV antimicrobial drug waste leading to significant JW modifier revenue losses.
- Difficulty tracking rapid re-authorization cycles tied to patient CD4 counts and viral loads.
- High administrative burden billing complex travel medicine panels and international vaccine series.
Challenges we solve for infectious disease
The work that generic platforms leave to your staff is the work infectious disease margin actually turns on.
Antiretroviral Authorization
Real-time step-therapy crosscheck auto-populates clinical evidence for same-day authorization.
IV Antimicrobial Waste
Vial-to-billing reconciliation automatically calculates and claims residual waste units.
Lab-Triggered Renewals
Lab result feeds automatically trigger authorization renewal workflows when thresholds are met.
Legacy software vs. Unlimited Systems
See why infectious disease practices move off general-purpose billing platforms.
CRITERIA
LEGACY SYSTEM COMPROMISE
UNLIMITED SYSTEMS VALUE
Antiretroviral Authorization
✕Manual step-therapy documentation delays HIV treatment initiation by days.
✓Real-time step-therapy crosscheck auto-populates clinical evidence for same-day authorization.
IV Antimicrobial Waste
✕Drug waste on high-cost IV antibiotics goes unclaimed due to missing JW modifier workflows.
✓Vial-to-billing reconciliation automatically calculates and claims residual waste units.
Lab-Triggered Renewals
✕Authorization renewals linked to CD4/viral load thresholds are missed without calendar tracking.
✓Lab result feeds automatically trigger authorization renewal workflows when thresholds are met.
Still evaluating
Not Ready to Switch Yet? That's Exactly When to Start the Conversation.
You don't have to be actively replacing your current system to have a useful conversation with Unlimited Systems. Many infectious disease practices talk with us months before a contract renewal or system evaluation to understand where OPAT billing, long-acting antiretroviral scheduling, 340B documentation, and culture documentation may already be showing up.
A conversation can help identify where OPAT administration coding, Cabenuva schedule-based dispensing, Part B versus Part D channel decisions, and 340B compliance documentation may be putting revenue at risk.
Less billing work between the visit and payment
Specialty rules and connected data keep your team focused on the exceptions that need judgment.
Verify before the visit
Coverage and authorization stay tied to the order.
Validate specialty charges
Code, unit, and modifier checks happen before filing.
Work the right accounts
Denials and A/R are ranked by value and filing risk.
35%less manual workflow time
One platform
The rest of the platform your infectious disease practice runs on
The same connected system handles the operational work that sits either side of billing.
Patient Intake
Digital intake, eligibility, and demographic capture before the visit.
Explore Patient IntakePatient Scheduling
Smart calendars and resource scheduling across providers and locations.
Explore Patient SchedulingFinancial Clearance
Automated eligibility checks and prior authorization management.
Explore Financial ClearanceCharge Validation
Pre-claim scrubbing for coding, modifiers, and compliance accuracy.
Explore Charge ValidationBuilt for infectious disease
Follow one infectious disease patient from intake to payment
Eight stages, one record. Nothing is rekeyed between systems, so a detail captured at the front desk is still there when the claim goes out, and when the remittance comes back.
Walk the workflow with us- 1Patient Intake for infectious diseaseDigital intake and demographic capture built around infectious disease visit types.
- 2Patient Scheduling for infectious diseaseCalendars and resources that reflect how infectious disease appointments actually run.
- 3Financial Clearance for infectious diseaseEligibility and prior authorization resolved before the patient arrives.
- 4Charge Validation for infectious diseaseSpecialty scrubbing on codes and modifiers before the claim leaves the building.
- 5Payment Posting for infectious diseaseERA and EOB posting reconciled automatically against what was billed.
- 6AR Management for infectious diseaseWorklists ranked by dollar value, aging, and timely-filing deadline.
- 7Healthcare Analytics for infectious diseaseLive visibility into denials, yield, and performance by provider and procedure.
- 8Value-Based Care for infectious diseaseQuality measures and episode costs tracked under alternative payment models.
Frequently asked questions
We support both commercial insurance and AIDS Drug Assistance Program (ADAP) billing pathways, correctly sequencing payer coordination rules to protect medication access for patients.
New to revenue cycle terminology? Browse our healthcare RCM & billing glossary.
We Love Hearing From Our Users
Practices like yours, on what changed after moving to Unlimited Financials.
★★★★★4.8/5
★★★★★5/5
“
The system continues to grow with features as it should, with how healthcare changes. So, if you are looking for a company that is innovative and truly cares, I would recommend Unlimited Financials.
Ernelita Dacumos
Billing Manager, SHOM
“
Unlimited Financials has been the easiest and best practice management system I have used. It is easy to navigate and do what I need to do.
Melissa Shook
Medical Biller, SHOM
“
We have been on Unlimited Financials for over three years and love it. Our claims are being processed faster and more efficiently, which means we are receiving payment more quickly.
Renee Bernacchi
Accounts Receivable Coordinator, COAS
“
Unlimited Financials has allowed us to extend our workforce in some areas due to the workflow efficiencies and given a better patient experience.
Mel Davies
CFO, Oregon Oncology Specialists
“
Knowledge of the patient's coverage has been a game changer. The ability to verify benefits before the patient comes in has saved us on time and denials, so there is no delay in treatment.
Alisha Haslem
Patient Advocate Manager, Utah Cancer Specialists
“
Using Unlimited Systems has allowed us to get a much better handle on our AR and claim management.
Erin Wilcher
Executive Director, Commonwealth Cancer Center
“
The system continues to grow with features as it should, with how healthcare changes. So, if you are looking for a company that is innovative and truly cares, I would recommend Unlimited Financials.
Ernelita Dacumos
Billing Manager, SHOM
“
Unlimited Financials has been the easiest and best practice management system I have used. It is easy to navigate and do what I need to do.
Melissa Shook
Medical Biller, SHOM
“
We have been on Unlimited Financials for over three years and love it. Our claims are being processed faster and more efficiently, which means we are receiving payment more quickly.
Renee Bernacchi
Accounts Receivable Coordinator, COAS
“
Unlimited Financials has allowed us to extend our workforce in some areas due to the workflow efficiencies and given a better patient experience.
Mel Davies
CFO, Oregon Oncology Specialists
“
Knowledge of the patient's coverage has been a game changer. The ability to verify benefits before the patient comes in has saved us on time and denials, so there is no delay in treatment.
Alisha Haslem
Patient Advocate Manager, Utah Cancer Specialists
“
Using Unlimited Systems has allowed us to get a much better handle on our AR and claim management.
Erin Wilcher
Executive Director, Commonwealth Cancer Center
Don't Love Your Current RCM Software Provider?
That's putting it nicely based on what we hear every day.
A support line that never picks up. An overseas call center that's never heard of your account. Errors nobody catches until the denial shows up. We're Midwest-based, not offshore, and the team that answers already knows your account. Practices that switch tend to wish they'd done it sooner.
- Located in Cincinnati, Ohio — no offshore call centers
- Founded by healthcare leaders, not tech-bros
- Industry leaders in innovation, technology, and automation
“I would recommend Unlimited Financials to other specialty practices.”
Michelle LeandriCEO, NEPA
“We transitioned to Unlimited Financials in 2024... the team and platform are absolutely amazing.”
GinaAdministrator, FOUR
“We have been on Unlimited Financials for over three years and love it. Our claims are being processed faster and more efficiently, which means we are receiving payment more quickly.”
Renee BernacchiAccounts Receivable Coordinator, COAS
GET STARTED
Optimize Your Specialty Revenue Cycle
Connect with a specialized Infectious Disease RCM expert for a personal workflow walkthrough, and see where your current setup is creating avoidable revenue risk.
★★★★★4.8/5★★★★★5/5★★★★★5/5
★★★★★5/5★★★★★5/56,500+ specialty providersSOC 2 certified